scholarly journals Management of the syndrome of inappropriate antidiuretic hormone secretion in small cell lung cancer

Cancer ◽  
1983 ◽  
Vol 51 (1) ◽  
pp. 161-165 ◽  
Author(s):  
John D. Hainsworth ◽  
Robert Workman ◽  
F. Anthony Greco
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Antidiuretic Hormone ◽  
Cell Lung Cancer ◽  
Hormone Secretion ◽  
Small Cell ◽  
Small Cell Lung ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion

scholarly journals Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future Implications

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Krishna Adit Agarwal ◽  
Myat Han Soe
Keyword(s):  
Lung Cancer ◽  
Case Report ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Hormone Secretion ◽  
Small Cell ◽  
Paraneoplastic Syndromes ◽  
Prognostic Impact ◽  
Small Cell Lung ◽  
Acth Secretion

We present a case of small-cell lung cancer (SCLC) with syndrome of inappropriate antidiuretic hormone secretion (SIADH) in which serum sodium gradually normalized with the onset of hypertension, refractory hypokalemia, and chloride-resistant metabolic alkalosis due to ectopic adrenocorticotrophic hormone (ACTH) secretion (EAS). In this case report, we discuss the diagnostic challenges of dual paraneoplastic syndromes with SIADH and EAS, management of SCLC with paraneoplastic endocrinopathies, and their prognostic impact on SCLC. In addition, we discuss neuroendocrine differentiation and ectopic hormone production in relation to intratumoral heterogeneity in SCLC and propose tumor microenvironment and hormonal and metabolic dependence as important determinants of tumor growth and survival.

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